HIJACKING ENDOCYTOSIS AND AUTOPHAGY IN EXTRACELLULAR VESICLE COMMUNICATION: WHERE THE INSIDE MEETS THE OUTSIDE

Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside

Extracellular vesicles, phospholipid bilayer-membrane vesicles of cellular origin, are emerging as nanocarriers of biological information between cells.Extracellular vesicles transport virtually all biologically active macromolecules (e.g., nucleotides, lipids, and proteins), thus eliciting phenotypic changes in recipient cells.However, we only par

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Functional role of N-linked glycosylation in human hepatic lipase: asparagine-56 is important for both enzyme activity and secretion.

Hepatic lipase (HL) and lipoprotein lipase (LPL) are evolutionarily related enzymes that are essential for normal lipoprotein metabolism.While much has been published on the structure-function relationship of LPL, little is known concerning the structural basis of HL action and secretion.Human HL is a glycoprotein and its predicted amino acid seque

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